Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0027	poly(I:G) Click for more detail	synthetic oligonucleotide (others)	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Scavenger receptor A II	Scavenger receptor (SR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8429030	1993	NA
PRRID_0027	poly(I:G) Click for more detail	synthetic oligonucleotide (others)	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Scavenger receptor A II	Scavenger receptor (SR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8429030	1993	NA
PRRID_0028	poly(I:G) Click for more detail	synthetic oligonucleotide (others)	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Scavenger receptor A II	Scavenger receptor (SR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8429030	1993	NA
PRRID_0028	poly(I:G) Click for more detail	synthetic oligonucleotide (others)	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Scavenger receptor A II	Scavenger receptor (SR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8429030	1993	NA
PRRID_0081	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	NA	Q9NR96.fasta	Q9NR96	1032	induce type I interferons (IFN) and other cytokines production.	NA	11130078	2000	Pubchem Assay
PRRID_0081	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	NA	Q9NR96.fasta	Q9NR96	1032	induce type I interferons (IFN) and other cytokines production.	NA	11130078	2000	Pubchem Assay
PRRID_0099	dsRNA Click for more detail	Type I Lang mammalian reovirus (virus)	NA	NA	Nucleic Acid	Natural	It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	(HEK293 t cells)	NA	O15455.fasta	O15455	904	IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.	EMSA	11607032	2001	Pubchem Assay
PRRID_0099	dsRNA Click for more detail	Type I Lang mammalian reovirus (virus)	NA	NA	Nucleic Acid	Natural	It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	(HEK293 t cells)	NA	O15455.fasta	O15455	904	IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.	EMSA	11607032	2001	Pubchem Assay
PRRID_0111	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	(HEK293 t cells)	NA	O15455.fasta	O15455	904	IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.	EMSA	11607032	2001	Pubchem Assay
PRRID_0111	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	(HEK293 t cells)	NA	O15455.fasta	O15455	904	IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.	EMSA	11607032	2001	Pubchem Assay
PRRID_0148	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0148	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0149	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0149	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0150	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0150	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0151	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0151	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0152	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0152	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0153	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0153	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0154	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0154	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0155	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0155	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0156	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0156	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0157	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0157	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0158	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0158	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0159	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0159	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0160	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0160	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0161	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0161	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0162	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0162	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0177	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58681.fasta	P58681	1050	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0177	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58681.fasta	P58681	1050	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0186	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58682.fasta	P58682	1032	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0186	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58682.fasta	P58682	1032	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0195	Double-stranded ribonucleic acid (dsRNA) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	ELISA	14976262	2004	Pubchem Assay
PRRID_0195	Double-stranded ribonucleic acid (dsRNA) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	ELISA	14976262	2004	Pubchem Assay
PRRID_0196	dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0196	dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0211	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0211	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0212	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0212	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0213	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	14976261	2004	NA
PRRID_0213	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	14976261	2004	NA
PRRID_0214	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	14976261	2004	NA
PRRID_0214	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	14976261	2004	NA
PRRID_0223	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58681.fasta	P58681	1050	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0223	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58681.fasta	P58681	1050	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0224	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58682.fasta	P58682	1032	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0224	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58682.fasta	P58682	1032	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0240	CpG-ODNs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0240	CpG-ODNs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0245	IC31 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0245	IC31 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0248	Poly (I:C)-LANAC Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Adjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Spleen and lung cells	NA	Q99MB1.fasta	Q99MB1	905	TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags.	ELISA	16751377	2006	Pubchem Assay
PRRID_0248	Poly (I:C)-LANAC Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Adjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Spleen and lung cells	NA	Q99MB1.fasta	Q99MB1	905	TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags.	ELISA	16751377	2006	Pubchem Assay
PRRID_0249	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0249	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0252	dsDNA Click for more detail	Adenovirus(virus)	NA	NA	Nucleic Acid	Natural	Adenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Plasmacytoid dendritic cells	NA	Q9NR96.fasta	Q9NR96	1032	This leads to the inflammatory response.	ELISA	17229689	2007	Pubchem Assay
PRRID_0252	dsDNA Click for more detail	Adenovirus(virus)	NA	NA	Nucleic Acid	Natural	Adenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Plasmacytoid dendritic cells	NA	Q9NR96.fasta	Q9NR96	1032	This leads to the inflammatory response.	ELISA	17229689	2007	Pubchem Assay
PRRID_0263	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	macrophages and dendritic cells	NA	O15455.fasta	O15455	904	Induces pro-inflammatory cytokine response	NA	17573354	2007	Pubchem Assay
PRRID_0263	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	macrophages and dendritic cells	NA	O15455.fasta	O15455	904	Induces pro-inflammatory cytokine response	NA	17573354	2007	Pubchem Assay
PRRID_0265	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	17404301	2007	Pubchem Assay
PRRID_0265	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	17404301	2007	Pubchem Assay
PRRID_0266	3M-003 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	NA	NA	NA	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	NA
PRRID_0266	3M-003 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	NA	NA	NA	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	NA
PRRID_0267	3M002 (CL075) Click for more detail	NA	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58682.fasta	P58682	1032	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0267	3M002 (CL075) Click for more detail	NA	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58682.fasta	P58682	1032	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0268	852A Click for more detail	NA	CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O	NA	Nucleic Acid	Synthetic	It has stimulated the production of interferon-‚ç∫ (IFN-‚ç∫), IFN-inducible protein-10 (IP-10), interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),IL-12p70, IL-18, and IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood mononuclear cells (PBMC)	LRR	Q9NYK1.fasta	Q9NYK1	1049	It has inhibited the proliferation of tumor cell lines Hs294T and 769-P.	ELISA	18439103	2008	Pubchem Assay
PRRID_0268	852A Click for more detail	NA	CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O	NA	Nucleic Acid	Synthetic	It has stimulated the production of interferon-‚ç∫ (IFN-‚ç∫), IFN-inducible protein-10 (IP-10), interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),IL-12p70, IL-18, and IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood mononuclear cells (PBMC)	LRR	Q9NYK1.fasta	Q9NYK1	1049	It has inhibited the proliferation of tumor cell lines Hs294T and 769-P.	ELISA	18439103	2008	Pubchem Assay
PRRID_0269	852A Click for more detail	NA	CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O	NA	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	Q9NYK1.fasta	Q9NYK1	1049	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	Pubchem Assay
PRRID_0269	852A Click for more detail	NA	CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O	NA	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	Q9NYK1.fasta	Q9NYK1	1049	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	Pubchem Assay
PRRID_0274	Cardioprotectant adenosine Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Adenosine increases matrix metalloproteinase-9 production by primary macrophages from healthy volunteers and myocardial infarction patients.	Adenosine-A3 receptor	G-protein-coupled receptors (GPCR)	Human	PBMCs	NA	P0DMS8.fasta	P0DMS8	318	It improves the revascularization.	ELISA	18653544	2008	Pubchem Assay
PRRID_0274	Cardioprotectant adenosine Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Adenosine increases matrix metalloproteinase-9 production by primary macrophages from healthy volunteers and myocardial infarction patients.	Adenosine-A3 receptor	G-protein-coupled receptors (GPCR)	Human	PBMCs	NA	P0DMS8.fasta	P0DMS8	318	It improves the revascularization.	ELISA	18653544	2008	Pubchem Assay
PRRID_0276	CL087 Click for more detail	NA	COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0276	CL087 Click for more detail	NA	COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0277	CL097 Click for more detail	NA	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58682.fasta	P58682	1032	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0277	CL097 Click for more detail	NA	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58682.fasta	P58682	1032	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0278	CpG ODN Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Salmo salar L.	Spleen and head kidney	NA	NA	NA	NA	It resulted into viral recognition, resulting in an enhanced innate immune response.	NA	18602433	2008	NA
PRRID_0278	CpG ODN Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Salmo salar L.	Spleen and head kidney	NA	NA	NA	NA	It resulted into viral recognition, resulting in an enhanced innate immune response.	NA	18602433	2008	NA
PRRID_0279	CpG2006 Click for more detail	NA	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	Q9NR96.fasta	Q9NR96	1032	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	Pubchem Assay
PRRID_0279	CpG2006 Click for more detail	NA	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	Q9NR96.fasta	Q9NR96	1032	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	Pubchem Assay
PRRID_0281	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	basal epithelial layer.	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0281	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	basal epithelial layer.	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0288	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0288	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0289	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0289	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0296	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0296	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA

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